Redox signaling and homeostasis has been increasingly recognized as an important component of cellular signal processing. We recently reported a redox-sensitive red fluorescent protein, rxRFP, which shows great potential<br/>to monitor redox dynamics in living cells. A group of rxRFP mutants have subsequently been developed to detect the redox activities in various subcellular domains, such as mitochondria, the cell nucleus, and endoplasmic reticulum (ER). Our work has expanded the fluorescent protein toolkit for studying redox dynamics and oxidative stress under various pathophysiological conditions.

Redox-sensitive red fluorescent proteins for imaging redox dynamics in cellular compartments

251st National Meeting (2016)

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