In this project a novel valerolactone based cross-linker was successfully synthesized from 5,6-dihydro-2H-pyran-2-one and 2,2'-(ethylenedioxy)diethanethiol via thiol-michael addition reaction. The synthesized cross-linker was characterized by <sup>1</sup>H NMR, <sup>13</sup>C NMR, and LC-MS. A novel three-dimensional, cross-linked hydrogel was synthesized from this cross-linker. The synthesized hydrogel is biodegradable due to the valerolactone backbone. The synthesized hydrogel will be used for drug delivery purposes. Drug loading and release behavior of the synthesized hydrogel will be investigated. A nanogel with a novel thermo-responsive hydrophilic shell and the same crosslinker will also be synthesized in the future.

Facile synthesis of biodegradable hydrogels for drug delivery applications

251st National Meeting (2016)

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