Tobacco is the leading cause of preventable deaths. Cytochrome P450 2A6 (CYP2A6) metabolizes about 80% of nicotine introduced to the body. Inhibition of nicotine metabolism has shown to result in longer periods between smoking urges and thus CYP2A6 is of interest as a potential smoking cessation aid. The present study seeks to investigate and characterize the ability of trans-cinnamic aldehyde, a dietary compound, and analogs of trans-cinnamic aldehyde to act as inhibitors of CYP2A6 activity. IC50 and Ks values for trans-cinnamic aldehyde and the 2-nitro and 4-nitro analogs with CYP2A6 will be presented.

Inhibition of cytochrome P450 2A6 by analogs of trans-cinnamic aldehyde

251st National Meeting (2016)

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