<i>Silica sol-gels synthesized through hydrolysis and condensation reactions via acid- and base-catalyzed procedures containing 4’,6-diamidino-2-phenylindole (DAPI) have been examined using surface-enhanced Raman (SERS) and fluorescence spectroscopy. DAPI is a Raman-active and fluorescent molecule that has traditionally been used in biosensors as a target molecule and a fluorescent stain known to bind strongly to the A-T rich regions of DNA. Sol-gels containing various concentrations of DAPI and silver nanoparticles for Raman-enhancement purposes were dried conventionally to form xerogels or supercritically to form aerogels and then analyzed using SERS and fluorescence spectroscopy to determine the effect of varying the silver to DAPI ratios.</i>

Examination of 4’,6-diamidino-2-phenylindole in silica gels through surface-enhanced Raman spectroscopy and fluorometry

251st National Meeting (2016)

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