Liposomes constitute established drug delivery systems (DDSs) for many hydrophobic, hydrophilic and amphiphilic drugs, due to their simplicity, formulation ease and excellent biocompatibility. Irrespective of drug nature, the bilayer composition is of critical importance since it controls the stability, drug loading and release properties of these DDSs.<br/><br/>We will present the interplay of these features in a recently optimized liposomal delivery system for a lipophilic experimental anticancer drug TUSP532 based on lipids and mixtures of lipids with gemini surfactants. The critical role of the packing parameter of amphiphiles used in liposomal formulation(s) on the stability, drug loading and drug release profile of these DDSs will be revealed through a combination of dynamic light scattering and zeta potential measurements, nano-differential scanning calorimetry (nanoDSC) and fluorimetry experiments. We will also present in vitro and ex vivo delivery experiments that will allow the full evaluation of the proposed technology in the detection of colon cancer.

Impact of amphiphile packing parameter on the drug loading and delivery properties of an anticancer liposomal delivery system

251st National Meeting (2016)

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