Aminopyronins are a relatively new family of fluorescent molecules that are being investigated to be used in biological research. Due to the distinctive characteristics of these molecules, such as relatively low toxicity, the ability to remain in the cytoplasm of cells investigated, and the relatively cost-effective processes required for its synthesis, aminopyronins are a promising class of fluorophore that can also be tailored to fulfill specific functions. Our research team has synthesized simpler aminopyronin molecules in the past with great success. In this investigation, we have been able to synthesize fluorinated aminopyronins with 4-Carbon side chains (n-butyl amine, tert-butyl amine, and diethyl amine). By using different methods of recrystallization specific to each type of molecule, we have been able to achieve high yields of products, and a good degree of purity. We describe procedures used to achieve these results, and point out the strategies used by our team to overcome the hurdles described by the literature for the synthesis of these molecules.

Synthesis of C<sub>4</sub>–substituted aminopyronins

251st National Meeting (2016)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.

Synthesis of C4–substituted aminopyronins

Synthesis of C₄–substituted aminopyronins