Metal-organic materials (e.g., meta-organic polyhedral (MOPs), metal-organic frameworks (MOFs), or coordination polymers) are a unique class of organic-inorganic hybrid materials with the potential for high stability, large ordered pore systems, and facile tunability (i.e., modularity). This is a burgeoning area that has gained much notoriety for the potential of the corresponding materials in various applications, with primary emphasis on the open frameworks as materials for gas capture/storage (e.g., CO2, H2, CH4) in energy and/or environmental applications, among others. Only recently have these organic-inorganic hybrid materials been targeted for biological applications (including, but not limited to, MRI contrast agents, chiral separations, enzyme encapsulation, heterogeneous catalysis, as well as drug delivery, nitric oxide sorption and release, and other controlled release applications). Our project focuses on another unique area related to biomedical applications, where we utilize MOF design principles to direct the organic synthesis of potential drug molecules, with special emphasis on naturally derived (biogenic) ligands.

(Metal-ligand)-directed organic synthesis of drug molecules from natural sources

251st National Meeting (2016)

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