Liposomal Spherical Nucleic Acids (LSNAs) represent a nanoscale arrangement of highly oriented oligonucleotides surrounding a spherical liposome as a template. LSNAs are a promising class of structures for enabling the potential of therapeutic nucleic acids. LSNAs show characteristics that are similar to SNAs with Au-nanoparticle cores, and the spherical arrangements of oligonucleotide strands is the key capability of LSNAs to enter multiple types of cells by endocytosis. In particular, the interactions of LSNAs with keratinocytes, tumor tissue, and cells of the immune system suggest two key ways to develop LSNAs as nanotherapeutics – as gene regulatory or immunomodulatory agents. LSNAs offer additional design features, such as those that enable the co-delivery of core-encapsulated or core-embedded drugs. Advanced designs, such as LSNAs featuring TLR-agonist oligonucleotides and co-functionalized with peptide or protein antigens, have shown promising activity as vaccines against cancer and infectious disease.

Liposomal spherical nucleic acids: Nanostructures enabling the potential of therapeutic nucleic acids

251st National Meeting (2016)

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