Dendrimers are synthetic polymers with a branched, treelike structure. The molecular architecture of dendrimers results in polymers that are well defined in their size and number of terminal groups. The nature of the terminal groups determines the particular dendrimer shape, stability, conformational rigidity or flexibility, and viscosity. Dendrimers contain arms, which are uniformly centered on the dendrimer core. The number of arms on a dendrimer is proportional to the dendrimer generation. We have designed and synthesized various ligands to conjugate to the dendrimer arms that will serve as unique attachment points for biologically relevant molecules. The click-chemistry ligands synthesized are 3-(4-(2-chloroethoxy)phenyl)propanoate, 3-(4-(prop-2-ynyloxy)phenyl)propanoate and 3-(4-(allyloxy)phenyl)propanoic acid. These ligands will be conjugated to the dendrimer arms using EDC coupling and then attached to the biological molecules using click-chemistry. The final dendrimer conjugates will ultimately be tested as potential drug delivery or gene delivery agents.<br/>

Synthesis of click-chemistry ligands for dendrimer functionalization

251st National Meeting (2016)

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