Creatine is most commonly used to enhance exercise performance and the use of creatine supplements has become widespread among athletes and exercise enthusiasts. Creatine also has been used in various studies as a potential therapeutic agent for neuromuscular and neurodegenerative diseases. Due to creatine’s moderate solubility in water, the synthesis of a creatine salt with an increased solubility and stability are the goals of this research.  More specifically, the synthesis of creatine gluconate will be compared to creatine ascorbate, a previously successful and optimized creatine salt derivative, and pure creatine.  Various stoichiometries of creatine and D-gluconic acid were reacted using different solvents and reaction time in order to improve the product yield. Temperature and reaction time were also examined throughout the experiment to optimize the reaction. The synthesized products were examined and characterized with NMR. Additionally, the solubility of the new product was also determined. <br/>

Comparison of stability and solubility of creatine gluconate to creatine ascorbate

251st National Meeting (2016)

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