Over the past several years, many bacterial strains have grown immune to the effects of different drugs at an alarming rate. For this reason, the creation of new compounds, capable of eliminating harmful bacterial strains, is an ongoing battle that never ends. Studies have demonstrated that 90% of drugs are given orally, which means that these new compounds must be soluble in an aqueous medium. To obtain salts that are derived from ferrocenyl chalcones soluble in aqueous medium is the main focus of study of our research. Our main interest accents on the synthesis and electrochemical studies of monosubstituted ferrocenyl chalcones salt derivatives and explore their anti-bacterial activity. Specifically, this research works with dimethyl amines and pyridines as substituents and preparing their corresponding salts. We had obtained these products in moderate to good yields by a nucleophilic substitution in their nitrogen. Our target is to improve their bioavailability, solubility in water, and their anti-bacterial activity. The synthetic methodology, characterization, and preliminary biological assays of these compounds will be elaborated.

Synthesis and characterization of monosubstituted ferrocenyl chalcones salts derivatives: Study of their electrochemistry and antibacterial properties

251st National Meeting (2016)

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