Recent work has identified hydroimidazolones as active anti-oxidant compounds with limited stability after oxidation under physiological conditions. Modification of this heterocycle leads to more stable oxidation products while maintaining the desired anti-oxidant activity. These modified heterocycles are based on readily available phenylglycine as their starting material. The activity of these heterocycles has been assayed and found to be similar to the known heterocycles. Their synthesis and characterization will be presented.

Synthesis and evaluation of phenylglycine-derived heterocycles as anti-oxidants

251st National Meeting (2016)

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