Pyrrolizidine alkaloids (PA’s) are potentially toxic, naturally occurring secondary products, typically found in the plant family Asteraceae. As part of an alkaloid analysis of the Asteraceae family, multiple species of the cacalioid section of the family were analyzed to establish pyrrolizidine alkaloid content. Previous work examined three different species, Psacalium decompositum, Arnoglossum plantagineum, and Yermo xanthocephalus generating their GC-MS PA profiles. Subsequent efforts focused on the structural elucidation of the major PA's using NMR techniques. Current work aims to establish identities of a number of novel minor otonecine and platynecine based PA's that have been discovered in our laboratory from these three sources.

Structural elucidation of novel pyrrolizidine alkaloids from cacalioid Asteraceae

251st National Meeting (2016)

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