The outline for optimal design for interactions with a specific biological target is a challenge in molecular features. This takes research to a new level to accomplish the cure of the more outrageous diseases, including cancer. Compounds with similar characteristics or structural design related to colchicine, have been the epicenter of tumor studies, this can include but not limited to combretastatin A-4 and derivatives of it. Based in a chalcone framework, these products have been promising candidates for the restorative mechanisms of cancer. The literature highlight that merging ferrocene in the structural backbones of known compounds upgrades the capability of bioactive potential. Besides, the combination of heterocycles is a refinement that has roused the examination of future plans for the improvement in the capability of other bioactive compounds. It has been emphasized that the fuse of heterocycles can likewise make a change in their therapeutic impact. Among the alkene-functionalized derivatives, the incorporation of the epoxide group to the chalcones core is one of the main groups focused in the literature. There have been combretastatin epoxide analogues that have been tested for cytotoxicity in melanoma (B16) and leukemia (L1210) cancer cell lines, with IC50 from 25 to &gt;100 μM. Our synthetic approach foresees entirely these properties, demanding an importance to ferrocenyl chalcones and the addition of heterocycles to their structure. We are leading our specific purpose, with a study to determinate essential structural properties of compounds to predict or correlate biological properties. We are aiming to synthesize and characterize ferrocenyl chalcones epoxide derivatives via a Darzen reaction from ferrocenecarboxaldehyde and ∝-chloroacetophenones. Precursors for epoxide derivatives have been achieved in moderate to good yields. They have been characterized by <sup>1</sup>H and <sup>13</sup>C NMR spectra. Likewise, methoxy, fluorine, and nitro substituent groups have been incorporated in the compounds, based on the literature reviewed, as the most prominent for cancer treatment. Synthetic methodology and characterization of these compounds will be elaborated.

Aiming for ferrocenyl epoxide derivatives to explore their biological potential as anticancer compounds

251st National Meeting (2016)

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