Amides are formed conventionally in condensation reactions using an amine and carboxylic acid in the presence of strong acid and under harsh conditions. Flow chemistry offers an alternative for amide synthesis providing a reduction in hazardous waste and a potentially safer synthesis. We have built a flow chemistry reactor to produce amides using a continuous flow of reagents composed of a HPLC column packed with a TiO<sub>2</sub> a catalyst. Numerous variables such as flow rate, uniform temperature control, and pressure can be monitored rapidly and altered with this method. By using phenylacetonitrile and acetonitrile derivatives, coupled with aryl and aliphatic amines, various amides have been synthesized using this flow chemistry method.

Development of a continuous flow method with nitriles and amines substrates to form amides

251st National Meeting (2016)

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