Pierce’s Disease in grapevines is an economically devastating infection caused by the bacterium Xylella fastidiosa (Xf). In previous studies, our lab identified radicinin, an Xf-inhibitory natural product of Cochliobolus sp. isolated from grapevines resistant to Pierce’s Disease. We have isolated seven additional strains of endophytic fungi from grapevines that inhibit the growth of Xf in vitro, belonging to Geomyces, Eurotium, Cryptococcus and Ulocladium. We hypothesize that these strains of fungi also produce secondary metabolites that inhibit the growth of Xf, thereby protecting the winegrapes from Pierce’s Disease. We report the results of bioassay-guided isolation of active compounds produced by these strains of fungi.

Bioassay-guided isolation of secondary metabolite inhibitors of Xylella fastidiosa produced by endophytic fungi

251st National Meeting (2016)

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