A large amount of chemosynthetic nano-drug carriers has to be used to administer a needed dose of a drug. However, high doses of these excipients may cause the emergence of toxic potential to the patients. The use of non-toxic materials in pharmaceutical formulations could minimize the adverse effects of pharmaceutical residues entering the body and environment. Ginsenoside is a main bioactive constituent of herb Panax ginseng. Here, we show that self-assembly of the ginsenoside Rb1 with anticancer drugs leads to the formation of stable nanoparticles, which have greater anticancer effects in vitro and in vivo than the free drugs. The obtained nanoparticles possessed appropriate size, high drug loading efficiency, slowly drug release rate, higher blood circulation half-time of free betulinic acid and oleanolic acid. Furthermore, the antitumor effect of the nanoparticles in a mouse tumor xenograft model exhibited much better tumor inhibition efficacy and fewer side effects than that of free drugs, strongly supporting their application as efficient carriers for anticancer therapyA large amount of chemosynthetic nano-drug carriers has to be used to administer a needed dose of a drug. However, high doses of these excipients may cause the emergence of toxic potential to the patients. Green chemistry aims to develop green nanoparticles loaded with drugs to reduce the use of toxic and harmful ingredients in the production process and provide the lower-dose prescribing for medical treatments. The use of non-toxic materials in pharmaceutical formulations could minimize the adverse effects of pharmaceutical residues entering the body and environment. Ginsenoside is a main bioactive constituent of herb Panax ginseng. Here, we show that self-assembly of the ginsenoside Rb1 with anticancer drugs leads to the formation of stable nanoparticles, which have greater anticancer effects in vitro and in vivo than the free drugs. The obtained nanoparticles possessed appropriate size, high drug loading efficiency, slowly drug release rate, higher blood circulation half-time of free betulinic acid and oleanolic acid. Furthermore, the antitumor effect of the nanoparticles in a mouse tumor xenograft model exhibited much better tumor inhibition efficacy and fewer side effects than that of free drugs, strongly supporting their application as efficient carriers for anticancer therapy

Novel nano-drug carrier based on ginsenoside Rb1

251st National Meeting (2016)

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