One of the most challenging and clinically important goals in nanomedicine is to deliver imaging and therapeutic agents to solid tumors. Here we report the design and development of stimuli-responsive smart nanoparticles for targeting the the acidic microenvironments of solid tumors. By targeting the broad tumor habitats rather than tumor-specific receptors, this strategy has the potential to overcome the tumor heterogeneity problem and could be used to design diagnostic and therapeutic nanoparticles for a broad range of tumors.

Smart pH-activated nanoparticles for targeting the tumor microenvironments

251st National Meeting (2016)

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