Natural products have been an excellent resource in the discovery and development of pharmacological agents throughout history.  Chalcones, a type of flavonoid and natural product, are found in many plants and have been shown to have cytotoxic activity.  A small library of 30 chalcone derviatives has been designed and synthesized using basic aldol condensation in good yield. The cytotoxic activity of this library has been measured against ovarian cancer cells (OVCAR-3) resulting in the identification of lead compounds.

Synthesis and biological evaluation of a library of chalcones as cytotoxic agents

251st National Meeting (2016)

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