A discussion of the impact solvent1,2,3,4 and reagent5,6 guides can have on behaviours in chemistry. How might behaviours be shaped by visible monitoring of overall usage of solvents and reagents and increased awareness of E-factor, PMI or other metrics such as molar efficiency.7 1CHEM21 selection guide of classical- and less classical-solvents Green Chem., 2015, 17, 4848 – 4848 2Updating and Expanding GSK’s Solvent Sustainability Guide Manuscript in preparation. 3Development of a Solvent Selection Guide for Aldehyde-based Direct Reductive Amination Processes Green Chem., 2013, 15, 1159-1165 4Evaluation of Alternative Solvents in Common Amide Coupling Reactions: Replacement of Dichloromethane and N,N-Dimethylformamide Green Chem. 2013, 15, 596-600 5Development of GSK’s Reagent Guides – Embedding Sustainability into Reagent Selection Green Chem. 2013, 15, 1542-1549 6Development of GSK’s Acid and Base Selection Guides Green Chem.2015, 17, 945-949 7Molar Efficiency: A Useful Metric To Gauge Relative Reaction Efficiency in Discovery Medicinal Chemistry ACS Sustainable Chem. Eng., 2014, 2 (3), 523-532

Use of tools and metrics to drive culture change in R&D chemistry

251st National Meeting (2016)

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