The effect of anti-inflammatory drug, diclofenac sodium (DS) on the transformation of various surfactant aggregates from spherical micelles to vesicles via branched worm-like micelles of two ionic liquid based surfactants (ILBs), 1-(1-hexadecyl)-3-vinyl imidazolium bromide, [C16Vim][Br], 1-(1-hexadecyl)-3-methyl imidazolium bromide [C16Mim][Br] and cetyltrimethyl ammonium bromide, CTAB were evaluated in aqueous solution at 298.15 K. Turbidity, viscosity, dynamic light scattering (DLS) and transmissions electron microscopy (TEM) measurements were used to study the DS-induced formation of unilamellar vesicles of different sizes. From the viscosity data we found that transition of spherical micelles to wormlike micelles occurred at low concentration of DS for [C16Vim][Br] as compare to [C16Mim][Br] and CTAB. This shows a stronger interaction between cations of ILs and Anions of the drug. Hydrodynamics diameter obtained from DLS and TEM analysis revealed that DS/[C16Vim][Br] mixtures in aqueous solution lead to the formation of large unilamellar vesicles compare to DS/[C16Mim][Br] and DS/CTAB. These systems have potential application in drug delivery. We thank DST and TEQIP Travel Grant (India) and FAPESP (State of São Paulo Research Foundation, Brazil) for support.

Diclofenac sodium-induced micelle-to-vesicle transition in ionic liquid based surfactant systems: Relevance to drug delivery

251st National Meeting (2016)

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