<br/>The U.S. Food and Drug Administration’s (FDA’s) primary mission is to promote and protect public health. FDA's Center for Food Safety and Applied Nutrition (CFSAN) is one of six product-oriented centers within the FDA that carries out the mission of FDA to enforce the Federal Food, Drug, and Cosmetic (FD&C) Act and other laws that are designed to protect consumers' health and safety. The Office of Food Additive Safety (OFAS) within CFSAN manages FDA's pre-and post-market safety review of food additives, color additives, food contact substances, and generally recognized as safe (GRAS) substances. A result of OFAS’ responsibilities, it has amassed a very large volume of chemical, toxicological and regulatory data on chemicals under its purview. As such, OFAS has developed a number of web-based informatics tools that link regulatory submissions, regulations, chemical data and toxicological data to facilitate the identification of the regulatory history of a particular chemical as well as the chemical and toxicological data available within our internal administrative files. STARI is an ontology of scientific and foods terminology and regulatory data,<br/>organized in a multi-hierarchical structure, and cross-linked to CERES and other data resources. CERES is OFAS’ chemical-centric knowledgebase that links regulatory history with human intake estimates and toxicological data in one resource. CERES also provides informatics tools to probe potential toxicity as well as identify potential structural analogs for read-across approaches to assist in the safety evaluation of new and previously regulated food additives and ingredients.

Harnessing chemical and toxicological data for the evaluation of food ingredients and packaging

251st National Meeting (2016)

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