Glycation is the non-enzymatic reaction between proteins and reducing sugars that leads to the formation of advanced glycation endproducts (AGEs). The formation and accumulation of AGEs lead to several chronic human illnesses including type-2 diabetes and neurodegenerative diseases. The traditional Indian Amla (Phyllanthus emblica) fruit (also known as Indian gooseberry) has been linked with a wide variety of biological effects including anti-diabetic effects. Moreover, published data suggest that Amla extracts show anti-AGE effects but the active compounds were not identified. Herein, we report the isolation and structure elucidation (by NMR) of ten (1-10) compounds from a commercial Amla juice powder, which included six gallotannins/gallic acid derivatives and four ellagitannins/ellagic acid derivatives. The anti-AGE effects of the Amla extract and pure compounds were investigated using a combination of in vitro (BSA-fructose assay) and in vivo (Caenorhabditis elegans) assays.

Advanced glycation endproducts inhibitory compounds from amla (Phyllanthus emblica)

251st National Meeting (2016)

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