Self-assembly by means of coordinative bond formation has opened up opportunities for the high yield synthesis of molecules with complex topologies. However, the preparation of purely covalent molecular architectures in aqueous media has remained a challenging task. Here, we present the preparation of a 3D catenane in a weakly acidic aqueous solution, through an almost quantitative self-assembly process relying on dynamic hydrazone linkages. The present study thus details a simple approach to the creation and control of complex molecular architectures under reaction conditions that mimic biological milieus.

Self-assembly of complex molecular architectures based on dynamic hydrazone linkages in water

251st National Meeting (2016)

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