Acrylamide, a primary amide, is neurotoxic and potentially carcinogenic to both humans and animals. It can be formed while cooking foods at high temperature and from the oxidation of asparagine at physiological conditions. Acrylamide is metabolized majorly by heme-containing cytochrome P450 2E1, producing glycidamide, which is considered to play the main role in acrylamide carcinogenicity. Recently, an acrylamide analogue was found as a heme-dependent sGC (soluble guanylyl cyclase) activator, resulting in smooth muscle relaxation. The nitric oxide (NO)-like effect through the heme interaction is a possible pathway for the activation by the acrylamide analogue. Thus, it is very interesting to study the interactions between acrylamide and various heme models. In this study, a series of five- and six-coordinate acrylamide manganese porphyrin complexes has been prepared and structurally characterized. The redox behavior of the resulting complexes have also been investigated.

Synthesis, characterization, and electrochemistry of acrylamide manganese porphyrin complexes

251st National Meeting (2016)

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