Hepatitis B virus infection is a common cause of severe liver disease and liver cancer. Current treatment options cannot fully suppress viral replication in the majority of patients and only show very low cure rates. Accordingly, the identification of antivirals with a new mechanism of action should allow for the intensification of HBV suppression towards fully blocking HBV production in the liver and thus improve treatment outcomes toward the identification of a cure. The HBV core capsid protein has multiple essential functions in the HBV life cycle to enable chronic HBV infection. It is therefore an important target for antiviral drug development. Herein we describe the identification of a novel series of indole-based HBV core protein modulators and propose a mode of binding at the core protein dimer-dimer interface.

Identification of a novel series of indole core protein modulators of the hepatitis B virus

251st National Meeting (2016)

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