Starburst dendrimers were first introduced in the 1980’s by D.A. Tomalia and have since had their properties studied in detail. This study focuses on the synthesis of first generation PAMAM starburst dendrimers to determine if a more efficient method could be found. The literature found describes detailed analysis of the structure and its possible functions but lacks detailed information about an improved synthesis, other than from Tomalia. It is known that as temperature increases so does the rate of reaction and this could be used to improve the synthesis. A direct approach was taken to alter the concentration of one reactant and the temperature of the environment to determine the effects on the synthesis. With an improved process, higher quality and more dendrimers could be produced per synthesis and thus be more available for study and use.

Optimization of first generation poly(amidoamine) starburst dendrimer synthesis

251st National Meeting (2016)

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