The fluorescence of Thioflavin T (ThT) is commonly used for detection of amyloid plaques associated with Alzheimer’s disease. However, ThT has yet to be considered as a two-photon fluorescence probe, which would introduce many advantages. Herein, we report the theoretical-experimental characterization of the two-photon absorption and up-conversion fluorescence spectra of ThT. Our results show the excellent nonlinear absorption of ThT which is expected to expand its application to bioimaging.

Multiphoton spectroscopy on thioflavin T: A nonlinear approach for amyloid detection

251st National Meeting (2016)

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