Five new tetracyclic diterpenoids (1 – 5) of the class briarellin were isolated from the methanolic extract of the gorgonian octocoral Briareum asbestinum collected off the coast of South Florida. Compounds 1 – 3 are the first series of briarellins possessing oxygenation at C-13, and Compounds 2 – 5 are the first series of briarellins possessing oxygenation at C-15. The structures were determined by spectral analysis including NMR and MS. Compounds 1 – 3 were found active against three human cell lines.

Isolation and structural elucidation of tetracyclic diterpenoids from marine soft coral Briareum asbestinum

251st National Meeting (2016)

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