Virus Like Particles (VLPs) are the engineered and semi-synthetic derivatives of virus capsids—the shell-like structure that encapsulates the viral genome—which serve as the basis of new nanomaterials for drug delivery, <i>in vivo</i> detection of disease and in self-assembled materials. Their broad appeal arises from the fact that VLPs are highly extensible and can be modified by site-specific mutagenisis or chemical transformations post-expression to add new functionality. Our research has focused on developing methodology for organic chemcial transformations within the current scope and beyond traditional bioconjugation techniques to create supramolecular nanocontainers that enable environmentally responsive behavior. My talk will present our efforts toward this objective and the progress we have made during the initial two years of our research.

Virus-like-particles in advanced materials applications

251st National Meeting (2016)

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