Magnetic nanoparticles created tremendous interest in biological application for cancer treatment with targeted drug delivery and hyperthermia. Superparamagnetic materials based on iron oxides magnetic properties are strongly influenced by dispersion and particle size. Alternative materials having higher superparamagnetic properties such as iron carbides and carbon-coated Fe were explored. [1] The presence of carbon shell acts as a protective coating against chemical components of biological fluids and is inert to pH change. Along with magnetic properties, simulations of fluorescence properties by the same particles can eliminate the addition of organic fluorophores (dyes) required for biological imaging. The paper presents the synthesis of hybrid Fe@C-CNx core-shell nanoparticles exhibiting both superparamagnetic and fluorescence properties. Superparamagnetic Fe@C core-shell nanoparticles were used where the carbon shell was functionalized through the one-step free-radical addition of alkyl groups terminated with carboxylic acid moieties. [2] The method utilizes the organic acyl peroxide of dicarboxylic acid (succinic acid peroxide) as precursor for functionalization. Further, functionalized nanoparticles were coated with CNx through a low-temperature, in-situ solution-based chemical reaction of cyanuric chloride with lithium nitride. [3, 4] A detailed physiochemical characterization and fluorescence property of the hybrid materials is presented. References 1. Davydov V., Rakhmanina R., Kireev I., Alieva I., Zhironkina O., Strelkova O., Dianova V., Samani T., Mireles K., Yahia L. H., Uzbekov R., Agafonov V., Khabashesku, V., Solid state synthesis of carbon-encapsulated iron carbide nanoparticles and their interaction with living cells.- J. Mater. Chem. B, 2014,2, 4250-4261. 2. Peng H., Alemany L., Margrave J.L., Khabashesku V.N. - Sidewall Carboxylic Acid Functionalization of Single-Walled Carbon Nanotubes. - J. Am. Chem. Soc., 2003, 125, 15174-15182. 3. Zimmerman J.L., Williams R., Khabashesku V.N., Margrave J.L. -Synthesis of Spherical Carbon Nitride Nanostructures. - Nano Letters, 2001, 1, 743-747. 4. Ryabova A.V., Zinin P.V., Davydov V., Khabashesku V., Boritko S., Sharma S., Loshenov S. - Anomalous fluorescence of the spherical carbon nitride nanostructures. - Chem. Phys. Lett., 2015, 633, 95–98.

Fluorescence properties of hybrid core-shell superparamagnetic Fe@C-CNx nanoparticles

251st National Meeting (2016)

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