Hydrogen sulfide (H2S), traditionally known as a venomous gas with a stinky smell, has been recently recognized as an important signaling molecule. H2S is a highly reactive molecule that can react with many biological targets. These reactions make the detection of H2S in biological systems very challenging. In this presentation, I will report our work in the development of reaction-based fluorescent probes for H2S. We have discovered several diselenide and selenol based templates that can selectively react with H2S. These templates are used to develop fluorescent probes which have shown excellent sensitivity and selectivity for H2S over biothiols (such as cysteine and glutathione) and other reactive sulfur species.

Development of reaction-based fluorescent probes for hydrogen sulfide

251st National Meeting (2016)

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