Ion mobility-mass spectrometry (IM-MS) provides size-based separations of gas-phase ions and when coupled with electrospray ionization (ESI), it has enormous potential for structural characterization of biomolecules. The question is, do ions formed by ESI maintain their solution-like conformations as solvent is removed by droplet fission and solvent evaporation in the transition from solution to solvent-free, gas phase ions? This lecture will focus on a series of experimental and molecular dynamics (MD) simulation studies that are specifically designed to provide answers to these questions.

Mass spectrometry and structural biology: Ion mobility-mass spectrometry studies of water and water-mediated conformational preferences of peptides and proteins

251st National Meeting (2016)

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