Recently, a green and efficient method of developing substituted aromatic silyl ketones has been conducted in our labs. These silyl ketones will be used to form an intermediate that could undergo a simple ring closure that would provide a cyclic ether compound (Product 1). Alternatively, the intermediate could undergo a Brook rearrangement that would form a ring structure with a Si-O bond (Product 2). Initial studies have shown that the benzoyl silane compounds primarily undergo the rearrangement reaction. By studying our library of aromatic silyl ketones, we hope to determine specific trends in the reaction products that result from the nature and position of groups on the benzene ring.

Cyclization studies of intermediates derived from aromatic silyl ketones

251st National Meeting (2016)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.