We present an injectable hydrogel system for dual drug delivery using oxime click chemistry by employing a ketone-functionalized polyester and an amino-oxy functionalized polyglycidol. The biocompatibility and orthogonal nature of this chemistry makes these gels an attractive option for the simultaneous delivery of both small molecule synthetic and large biological therapeutics. Additionally, the synthesis method allows for control over the properties of these materials based upon the ratio between the two components of the hydrogel. Because of the orthogonal nature of this crosslinking chemistry, these gels also have the potential to be utilized as a platform for a more complex delivery system, and can be used as a matrix to encapsulate an additional delivery vehicle. Polyester nanosponges formed using amine-epoxide chemistry have been previously synthesized in our lab and have been shown to be an effective delivery vehicle for a number of hydrophobic drugs, both <i>in vitro</i> and <i>in vivo</i>. These particles can be successfully entrapped within the gel matrix during the synthesis procedure. In addition, the bulk environment of the hydrogel material is ideal for the entrapment of a large protein or biological therapeutic. The properties of these materials and their suitability as a platform for dual delivery will be discussed.

Synthesis of an injectable hydrogel platform for dual drug delivery using oxime click chemistry

251st National Meeting (2016)

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