Many transition metal complexes of NSAIDs are known.<sup>1</sup> They exhibit a range of biological properties. However, they are not very effective against cancer cells. Examples of organometallic complexes of NSAIDs such as flufenamic acid are unknown. We have synthesized a series of organorhenium (polypyridyl) flufenamato complexes and many of them have been structurally characterized through X-ray crystallography. DNA-binding study through UV-visible spectrophotometry reveals that the complexes partially bind to DNA intercallatively. The cytotoxicity studies against U937 lymphoma cells confirm that some flufenamato complexes are strong anticancer agents. The IC-50 values are in the range of 2-3 µM. Therefore, there might be applications in the treatment of many cancers.

DNA-binding and cytotoxicity studies of some organorhenium flufenamato complexes

251st National Meeting (2016)

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