Chemiluminescence is the direct emission of light from an excited state formed in the course of an exothermic chemical reaction. Chemiluminescent emission does not require an excitation light source, providing high sensitivity with low background. Although chemiluminescence has proven to be an invaluable tool for clinical assays and in vitro diagnostics, there only limited examples of in vivo chemiluminescent imaging due to challenges associated with aqueous chemiluminescent efficiency, biocompatible triggering mechanisms, and energy transfer to produce red-shifted emission. By tailoring the molecular properties of chemiluminescent scaffolds, we have addressed these challenegs to provide a series of chemiluminescent imaging agents based on chemical triggers to initiate light production and molecular architectures that enable efficient energy transfer to red-shifted emission wavelengths for in vivo imaging. The development and imaging applications of these probes will be presented.

Triggered energy transfer chemiluminescence for in vivo imaging

251st National Meeting (2016)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.