Mycobacterium tuberculosis, the organism responsible for Tuberculosis (TB), claims approximately 1.5 million lives annually. Our goal is to rapidly synthesize new compounds that can act as M. tuberculosis inhibitors without the devastating off-target effects associated with the current treatment options for TB. By targeting scaffolds of secondary metabolites necessary for the virulence of M. tuberculosis, we hope to gain rapid access to an analogue that will both gain entry to the active site and inhibit the mycobacterium. The secondary metabolites we are specifically targeting contain a common biaryl motif. With our method, we plan to efficiently and rapidly access complex and biologically active natural products that contain the desired biaryl scaffold.

New synthetic methods for the rapid synthesis of biologically active biaryl scaffolds

251st National Meeting (2016)

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