Monoterpenoid indole alkaloids have attracted synthetic interest due to their structural complexity and their vast array of biological activities. Monoterpenoid indole alkaloids, which include the Aspidosperma andCorynanthe alkaloids, present many synthetic challenges due to their intensive poly-fused ring skeletons. The focus of this research is the diversification and efficient synthesis of these scaffolds towards more efficacious natural products with deep-seated structural changes. We report the synthesis of Corynanthe andAspidosperma analogues from tryptamine and tryptamine derivatives in two to three steps

Synthesis of poly-fused scaffolds of Corynanthe and Aspidosperma indole alkaloids

251st National Meeting (2016)

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