Asymmetric synthesis of organic compounds using chiral Lewis bases as the organocatalysts gained much attention and become a popular strategy. Many organocatalysts have been developed and used in the literature. Organocatalysts with phosphine oxide groups have also been synthesized. They showed good catalytic effect in the synthesis of organic compounds with high enantioselectivities and yields. We have also synthesized new phosphine oxide aziridinyl phosphonate Lewis bases and studied their organocatalytic effect on the enantioselective allylsilane addition to aldehydes and the direct aldol reaction of cyclohexanone with aldehydes. The synthesis of the new phosphine oxide type organocatalyts and the results of their organocatalytic effect will be presented at this conference. References: 1. Denmark, S. E.; Winter, S. B. D.; Su, X.; Wong, K. J. Am. Chem. Soc. 1996, 118, 7404-7405. 2. Kotani, S.; Shimoda, Y.; Aoki, S.; Sugiura, M.; Nakajima, M. Tethedron Lett. 2011, 52, 2834-2836. 3. Rossi, S.; Benaglia, M.; Genoni, A.; Benincori, T.; Celentano, G. Tetrahedron 2011, 67, 158-166.

New phosphine oxide type organocatalyts for the asymmetric synthesis of organic compounds

251st National Meeting (2016)

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