Late-stage C–H functionalization of heteroarenes is of particular importance to medicinal chemistry.  Significant changes in biological activity may be observed through systematic substitution of reactive C–H bonds, and synthetic strategies amenable to rapid structural diversification are especially useful in the context of determining structure activity relationships.  Radical additions to heteroarenes have been effective in functionalizing a varitey of heterocycles with a wide range radical sources.  However, many of these strategies require specialized reagents that are expensive or challenging to make.  Our lab is interested in using renewable, non-petroleum carbon feedstock as radical precursors that are capable of C–H functionalization.  We have recently made strides in this area generating and reacting radicals from materials and reagents that are common to many organic laboratories.  Multiple radical-based strategies will be discussed that describe simple synthetic methods that can be used to rapidly diversify a varitey of heterocyclic scaffolds.<br/><br/>

New strategies for radical additions to aromatic heterocycles

251st National Meeting (2016)

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