Flavonoids are capable of exhibiting a large range of biological activities including anti-inflammatory, anti-bacterial, anti-tumor and antioxidant. Also, flavonoids have been proven to be effective insecticides and even antidotes to certain snake bites. Recently, they were recommended for the treatment of allergic and inflammatory diseases. As a result of the biological activity of flavonoids, there is an interest in the development of synthetic procedures that can conveniently give access to these molecules and their derivatives. This project focuses on the synthesis of novel derivatives of flavonoids in room temperature ionic liquids (RTILs). RTILs are composed of ions, and have gained increasing attention as clean, multifunctional solvents for a variety of applications in chemical and pharmaceutical industries. Imidazolium and pyrrolidinium-based RTILs were synthesized and characterized in the lab. A series of flavonoids was synthesized from 2’-hydroxyacetopheneone and benzoyl chloride derivatives using RTILs as the solvent. The resultant flavonoid derivatives were purified and characterized using NMR spectroscopy. The efforts are underway to perform assays of the synthesized flavonoids to determine the biological activities.

Synthesis of flavonoids in room temperature ionic liquids

251st National Meeting (2016)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.