Cu-doped rod-shaped mesoporous silica nanoparticles (Cu-RSMSN) were synthetised by a new one-step approach based on in situ functionalization procedure referring to the phenomenon of micellar solubilization.1 The composite CuO/SiO2 system proved to be an efficient heterogeneous catalyst for a microwave-assisted three component 1,3-dipolar cycloaddition reaction of alkynes, benzyl or alkyl halides and sodium azide, in aqueous solution. The one-pot preparation of 1,4-dibustituted-1,2,3-triazole derivatives was straightforward and high yielding, due to the high copper dispersion at the pore surface supported by the measured high accessibility to the active site. The efficiency of the catalyst was also demonstrated upon recycling, making such synthesis a truly green process, with high step and solvent economy and avoidance of waste. Reference 1 Mnasri, N.; Nyalosaso, J.L.; Colacino, E.; Derrien, G.; Lamaty, F.; Martinez, J.; Zajac, J.; Charnay, C. ACS Sustainable Chem. Eng., 2015, 3, 2516–2525.

Copper-containing rod-shaped nano-sized silica particles for microwave assisted synthesis of triazoles in aqueous solutions

251st National Meeting (2016)

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