Dioxovanadium(V) complexes have been of interest for their medicinal applications. For example, salicylaldehyde semicarbazone complexes have been shown to exhibit anti-tumor activity toward kidney tumor cells (TK-10), and in one recent paper, they have shown to be YopH tyrosine phosphatase inhibitors. Also, peroxovanadium(V) complexes containing uracil or cytosine have shown insulin-like activity. In the lab, we have synthesized dioxovanadium(V) complexes with substituted salicylaldehyde semicarbazone ligands to see how they affect tumor growth in cancer cells relative to unsubstituted salicylaldehyde complexes. However, in the course of the synthesis of the 3-methoxysalicylaldehyde semicarbazone complex, we have observed some unexpected color changes, suggesting interesting redox or ligand behaviour. The color of the resulting complex is dependent on different synthetic strategies employed. Each of the three colors have a unique infrared spectrum. We will be presenting the results of EPR, cyclic voltammetry and reflectance spectroscopy studies in order to explain the structural changes seen during the synthesis of these complexes.

Synthesis and characterization of V<sup>V</sup>O<sub>2</sub>(3-methoxysalicylaldehyde semicarbazone)

251st National Meeting (2016)

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Synthesis and characterization of VVO2(3-methoxysalicylaldehyde semicarbazone)

Synthesis and characterization of V^VO₂(3-methoxysalicylaldehyde semicarbazone)