Biological activity and compatibility is one of the most important characteristics inherent in the production and characterization of synthetic polymer materials that interface with biological systems. Such polymers have recently been researched for use in a variety of medical applications, including, but not limited to, drug delivery, hemostasis, and tissue engineering. Herein we report the biocompatible properties of parallel series of novel highly absorbent PNIPAM-based polyacrylate gels and PEG-based polyurethane hydrogel foams, each independently developed to serve as separate components of a composite wound dressing concept. These materials exhibit the ability to efficiently bind platelets and fibrinogen to initiate blood clotting. Secondly, we demonstrate the ability to easily load and effectively deliver a variety of anti-microbial drugs. Finally, these polymers represent a passive surface for the binding and proliferation of a variety of eukaryotic cell types, indicating that these materials are an ideal candidate for tissue engineering scaffolds.

Bio-activity of a series of novel multi-functional bio-compatible polymers

251st National Meeting (2016)

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