In this work, silver nanoparticles were prepared by reduction procedure. They were then characterized using various characterization techniques; scanning electron microscope, energy dispersive X-ray spectroscope, thermogravimetric analyzer, X-ray diffractometer, Fourier transformed infrared spectroscope, Raman spectroscope and high-resolution transmission electron microscope. The silver nanoparticle were of around 40 nm average size. The UV spectroscopy showed a maximum absorbance of silver nanoparticles at about 400 nm. Raman spectra showed multi sharp peeks can be assigned for Ketoconazole molecule as peaks at (790 cm-1) for C-Cl stretching vibration , (1050cm-1) for C-O vibration, peak present at ( 1388cm-1) for C-H bend, C=C( aromatic ) stretching vibration present at (1610cm-1),and stretching vibration C=O detect at (1707cm-1). The intensity of C-O peak, increase with increase the concentration of KCZ solution. Raman spectra of Ketoconazole on Ag showed interaction between Ketoconazole and Ag lead to highly SERS enhance peak of KCZ at (1050cm-1), and slightly enhance a peak of C-Cl at (785cm-1). The peak intensity of KCZ at (1050cm-1) with Ag is stronger than without Ag/NPs, due to the excitation of surface Plasmon resonance on substrates as a result from the strong interaction between KCZ and Ag/NPs. These substrates are promising for SERS applications in other drugs characterization. Acknowledgment: The authors would like to acknowledge the support provided by King Abdulaziz City for Science and Technology (KACST) through project No. A.T.34-8. The authors would like also to acknowledge the support by King Fahd University of Petroleum and Minerals (KFUPM).

Silver nanoparticles synthesis as SERS substrates for ketoconazole determination

251st National Meeting (2016)

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