A range of benzimidazolium gemini amphiphiles were synthesized, varying chain lengths and counter anions. Using these molecules gels were prepared by dissolution in ethanol and water. Through stability testing - using rheology, and thermoreversability studies – the strongest gel was found to be 1,3-bis[3-octadecyl-1-benzimidazolio)methyl]benzene dibromide. Using this gel folic acid was incorporated as folic acid, sodium folate, and as a counter ion, and the stability and morphology of the gels with drugs was studied using inversion, rheology, x-ray diffraction, SEM, and AFM. The incorporation of folic acid was most successful when in the form of a folate counter-ion.

Optimization of low molecular weight organogelators for drug delivery

251st National Meeting (2016)

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