Several variations of Cu(I) catalysts have been reported for use in the preparation of 1,4-disubstituted 1<i>H</i>-1,2,3-triazoles. Some of these have been adopted in our lab to prepare triazoles containing fluorinated groups at the 1 and 4 positions. The method reported most often used sodium ascorbate and copper (II) sulfate to generate the copper(I) catalyst along with heating of the reaction mixture. Conventional heating and microwave heating methods were used. Another catalytic method used 1,3-bis(2,4,6-trimethylphenyl)-imidazolium copper(I) chloride as the catalyst, used no reaction solvent and required no heating. These methods will be compared by product yields and product purity of various fluorinated triazoles synthesized.

Comparison of synthetic methods for copper(I)-catalyzed fluorinated triazoles

251st National Meeting (2016)

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