The Hypericum plant genus has attracted widespread attention owing to the antidepressant and wound-healing properties of St. John’s Wort (H. perforatum). Phytochemical studies of several members of the Hypericum genus, including H. perforatum, have yielded a number of structurally diverse and biologically active secondary metabolites from the acylphloroglucinol, flavonoid, and xanthone classes. The range of biological activities exhibited by these compounds include anti-HIV, anticancer, antioxidant, antiviral, antibacterial, anti-inflammatory, and anti-depressant effects. As part of an ongoing study to discover new bioactive compounds from Hypericum plant species growing in Pennsylvania, an acetone extract of the leaves of H. densiflorum was purified by Sephadex LH-20 and silica gel column chromatography, followed by reversed phase HPLC. Six acylphloroglucinol derivatives, together with a flavonoid and a triterpene, were isolated and characterized by 1D and 2D NMR spectroscopic data.

Acylphloroglucinols from an acetone leaf extract of Hypericum densiflorum

251st National Meeting (2016)

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