We have synthesized a series of quinolone-2-carboxaldehyde thiosemicarbazone (QCA-TSC) ligands and their palladium(II) complexes and characterized them via <sup>1</sup>H NMR spectroscopy. These mono-anionic tridentate QCA-TSC ligands have been used in complexation reactions with Pd<sup>2+</sup>, using either potassium tetrachloropalladate(II) or another palladium(II) starting material, to form square planar metal complexes with the formula (Pd[QCA-TSC]Cl). We have performed some anti-proliferative MIC (minimum inhibitory concentration) studies of the QCA-TSC ligands and palladium(II) complexes using seven different microbes in order to determine their anti-microbial properties. Some of these complexes, such as the [Pd(QCA-tBTSC)Cl] complex, are highly active against gram positive bacteria.

Synthesis and NMR characterization of a series of quinoline-2-carboxaldehyde thiosemicarbazones and their palladium(II) complexes

251st National Meeting (2016)

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